The Arizona Cardinals defeated the Los Angeles Chargers 26-14 on Sunday in the NFL's biggest upset of Week 1. The Chargers entered as the league's largest favorites with a 9.5-point spread, making the loss particularly costly for survival pool players, per Yahoo Sports.

The Chargers' offense struggled significantly under new coordinator Mike McDaniel, with quarterback Justin Herbert failing to find rhythm in the team's new system. Late mistakes proved decisive in the loss, according to reporting on the game.

Cardinals coach Mike LaFleur became the first Arizona head coach to win his debut since Don Coryell, per Pro Football Talk.