The Buffalo Bills christened their new Highmark Stadium on Thursday Night Football with a 41-31 victory over the Detroit Lions. The game featured ceremonial elements befitting an inaugural event at the venue: per reporting from Associated Press outlets, the stadium hosted two national anthems—both the U.S. and Canadian anthems—along with fireworks and a packed house. Josh Allen scored a touchdown run during the contest, per Associated Press coverage.

The dual anthem presentation marked a first for Highmark Stadium, according to Reddit users tracking the broadcast. Separately, "Mr. Brightside" was played for the first time at the new venue during the game.

Beyond the opening-day pageantry, Bills edge rusher Greg Rousseau drew attention for his defensive performance. One analyst noted that Rousseau's sack pace through the Lions game was comparable to Hall of Fame standards, though he had previously operated somewhat under the radar as a steady 4-3 defensive end since being drafted 30th overall in 2021.