The Houston Astros defeated the Chicago White Sox 2-0 in the third game of their four-game series at Daikin Park on September 2. The Astros, holding a 1.0-game lead in the AL West, improved to 71-69 with the victory, while the White Sox fell to 73-66.

Right-handed pitcher Hayden Wesneski (now 5-1) was effective for Houston, striking out five batters over seven innings while allowing no runs. According to reporting, Nelson Velazquez went 1-for-2 and delivered the go-ahead single in the eighth inning. One source also credits Alex Bregman with a two-out, two-run single that came after back-to-back walks.

The White Sox struggled offensively despite a strong outing from Davis Martin, per multiple outlets. Chicago wasted the performance and was unable to capitalize on scoring opportunities, resulting in what one source described as "a master class in missed opportunities." The loss came in the series' pivotal third game.