SportsLine's computer model has released its Week 1 college football picks for 2026, backing Auburn and Cincinnati among its selections, per CBS Sports reporting from multiple writers covering the matchups.

The model's predictions span the week's slate of games, including LSU vs. Clemson and Ole Miss vs. Louisville, which multiple outlets identified as marquee Week 1 matchups. CBS Sports also reported separately on the computer's prediction for Penn State against Marshall, with the model backing the Nittany Lions at the spread of -24.5.

Espn separately reported on notable Week 1 storylines, including No. 11 Oklahoma's opener against UTEP with coach Brent Venables discussing the Sooners' preparation, and No. 9 Ole Miss defensive coordinator Pete Golding describing the pressure of preparing for No. 24 Louisville. CBS Sports also covered Alabama's season opener against East Carolina, where new starting quarterback Keelon Russell will make his debut for the Tide.